Manisri Porukala working under the supervision of Dr. P K Vinod presented a poster on Molecular Insights into the progression of precancerous to cancer state in Hepatocellular Carcinoma using gene co-expression analysis at the 42nd Annual Conference of The Indian Association of Cancer Research (IACR) held from 12 – 15 January at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Navi Mumbai.
Research work as explained by the authors:
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with alarming mortality rates among cancer-associated deaths globally. Surgical resection of tumour and liver transplantation are the primary options available for treatment but are prone to recurrence within a few years of surgery. Despite its high incidence, a few molecular-targets-based therapies have been reported to improve the survival rates of patients. Therefore, it is crucial to understand molecular mechanisms fuelling the pathogenesis of HCC to improve treatment therapeutics and biomarkers for timely prognosis. In this direction, we investigated publicly available RNA-seq data of precancerous and tumour samples procured from HCC patients undergoing primary treatment. A gene co-expression network-based framework was employed to get molecular insights from the transcriptomics data. Overall, the design of our study delineated underlying pathways within precancerous and tumour samples accounting for differences in DFS (Disease-free survival), and the progression from precancerous to cancer state.
Conference page: https://actrec.wixsite.com/iacr2023